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    Drug Uses

    Actoplus Met is used for treating type 2 diabetes. It is used along with diet and exercise. It may be used alone or with other antidiabetic medicines.

    How to use

    Use Actoplus Met as directed by your doctor. Check the label on the medicine for exact dosing instructions.
    An extra patient leaflet is available with Actoplus Met . Talk to your pharmacist if you have questions about this information.
    Take Actoplus Met by mouth with meals.
    Take Actoplus Met on a regular schedule to get the most benefit from it. Taking Actoplus Met at the same times each day will help you remember to take it.
    Continue to take Actoplus Met even if you feel well. Do not miss any doses.

    Drug Class and Mechanism

    Actoplus Met is a biguanide and thiazolidinedione antidiabetic combination. It works by decreasing the amount of sugar the liver produces and the intestines absorb. It also helps to make your body more sensitive to the insulin that you naturally produce.

    Missed Dose

    If you miss a dose of Actoplus Met , take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

    Storage

    Store this medicine at room temperature at 77 degrees F (25 degrees C) in a tightly-closed container, away from heat, moisture, and light. Brief storage between 59 and 86 degrees F (15 and 30 degrees C) is permitted.

    Warnings/Precautions

    Do NOT use Actoplus Met if:
    you are allergic to any ingredient in Actoplus Met
    you have type 1 diabetes
    you have moderate to severe heart failure
    you have a severe infection, low blood oxygen levels, kidney or liver problems, or high blood ketone or acid levels (eg, diabetic ketoacidosis), or you are severely dehydrated
    you have had a stroke or a recent heart attack, or you are in shock
    you are 80 years old or more and have not had a kidney function test
    you will be having surgery or certain lab procedures
    you have a history of liver problems, including jaundice (yellowing of the skin or eyes), during therapy with a similar medicine called troglitazone

    Contact your doctor or health care provider right away if any of these apply to you.

    Some medical conditions may interact with Actoplus Met . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
    if you are pregnant, planning to become pregnant, or are breast-feeding
    if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
    if you have allergies to medicines, foods, or other substances
    if you have a history of heart problems (eg, heart failure), abnormal liver function tests, lung or breathing problems, thyroid problems, stomach or bowel problems (eg, paralysis, blockage), adrenal or pituitary problems, eye or vision problems (eg, macular degeneration), bladder cancer, or lactic acidosis
    if you have fluid retention or swelling problems, vomiting, diarrhea, poor health or nutrition, low blood calcium or vitamin B12 levels, or anemia, or if you are dehydrated
    if you have an infection, fever, recent injury, or moderate to severe burns
    if you have a history of bone fracture, weak bones (eg, osteoporosis), or low calcium intake
    if you drink alcohol or have a history of alcohol abuse
    if you will be having surgery or certain lab procedures
    if you take a beta-blocker (eg, propranolol)
    Some MEDICINES MAY INTERACT with Actoplus Met . Tell your health care provider if you are taking any other medicines, especially any of the following:
    Amiloride, cimetidine, digoxin, morphine, procainamide, quinidine, quinine, ranitidine, triamterene, trimethoprim, or vancomycin because they may increase the risk of Actoplus Met 's side effects
    Calcium channel blockers (eg, nifedipine), corticosteroids (eg, prednisone), diuretics (eg, furosemide, hydrochlorothiazide), estrogen, hormonal contraceptives (eg, birth control pills), insulin, isoniazid, nicotinic acid, oral antidiabetics (eg, glipizide), phenothiazines (eg, chlorpromazine), phenytoin, sympathomimetics (eg, albuterol, pseudoephedrine), or thyroid hormones (eg, levothyroxine) because the risk of high or low blood sugar may be increased
    Gemfibrozil because it may increase the risk of Actoplus Met 's side effects
    Rifampin because it may decrease Actoplus Met 's effectiveness, resulting in high blood sugar
    Anticoagulants (eg, warfarin) because their effectiveness may be decreased or the risk of their side effects may be increased by Actoplus Met

    Possible Side Effects

    All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
    Cold-like symptoms; diarrhea; headache; indigestion; mild weight gain; nausea; stomach upset.

    Seek medical attention right away if any of these SEVERE side effects occur:
    Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blurred vision or other vision changes; bone pain; chest pain or discomfort; dark urine; difficult or painful urination; dizziness or lightheadedness; fainting; fast or difficult breathing; feeling of being unusually cold; general feeling of being unwell; muscle pain or weakness; pale stools; persistent loss of appetite; severe or persistent headache, nausea, or vomiting; shortness of breath; slow or irregular heartbeat; sudden unexplained weight gain; swelling of the hands, ankles, or feet; unusual stomach pain or discomfort; unusual drowsiness; unusual tiredness or weakness; yellowing of the eyes or skin.

    More Information

    If you have any questions about Actoplus Met , please talk with your doctor, pharmacist, or other health care provider.
    Actoplus Met is to be used only by the patient for whom it is prescribed. Do not share it with other people.
    If your symptoms do not improve or if they become worse, check with your doctor.
    If using Actoplus Met for an extended period of time, obtain refills before your supply runs out.
    Uses
    This combination medication is used along with a proper diet and exercise program to control high blood sugar in people with type 2 diabetes. Controlling high blood sugar helps prevent kidney damage, blindness, nerve problems, loss of limbs, and sexual function problems. Proper control of diabetes may also lessen your risk of a heart attack or stroke.

    Pioglitazone belongs to a class of drugs known as thiazolidinediones or "glitazones". Metformin and pioglitazone work by helping to restore your body's proper response to the insulin you naturally produce. Metformin also decreases the amount of sugar that your liver makes and that your stomach/intestines absorb.

    Talk to your doctor about the risks and benefits of using pioglitazone-containing products.

    How to use Actoplus MET
    Read the Medication Guide provided by your pharmacist before you start taking pioglitazone/metformin and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

    Take this medication by mouth as directed by your doctor, usually once or twice daily with meals to decrease stomach upset. Drink plenty of fluids while taking this medication unless otherwise directed by your doctor.

    The dosage is based on your medical condition, response to treatment, and other medications you may be taking. Be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). To reduce your risk of side effects (such as upset stomach), your doctor may direct you to start this medication at a low dose and gradually increase your dose. Follow your doctor's instructions carefully.

    Take this medication regularly in order to get the most benefit from it. Remember to use it at the same time(s) each day.

    If you are already taking another diabetes medication, follow your doctor's directions carefully for stopping/continuing the old drug and starting this medication.

    Check your blood sugar regularly as directed by your doctor. Keep track of the results, and share them with your doctor. Tell your doctor if your blood sugar measurements are too high or too low. Your dosage/treatment may need to be changed. It may take up to 2 to 3 months before the full benefit of this drug takes effect.
    Side Effects
    See also Warning section.

    Nausea, vomiting, stomach upset, diarrhea, weakness, sore throat, muscle pain, weight gain, tooth problems or a metallic taste in the mouth may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. If stomach symptoms return later (after taking the same dose for several days or weeks), tell your doctor right away. Stomach symptoms that occur after the first days of your treatment may be signs of lactic acidosis.

    Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

    Tell your doctor right away if you have any serious side effects, including: new/worsening vision problems (such as blurred vision), bone fracture, reddish-colored urine, urgent need to urinate, pain while urinating.

    Pioglitazone may rarely cause liver disease. Tell your doctor right away if you develop symptoms of liver disease, including: dark urine, yellowing of eyes/skin, persistent nausea/vomiting, stomach/abdominal pain.

    This medication usually does not cause low blood sugar (hypoglycemia). Low blood sugar may occur if this drug is prescribed with other diabetes medications (such as insulin or a sulfonylurea). Low blood sugar is more likely if you drink large amounts of alcohol, do unusually heavy exercise, or do not consume enough calories from food. To help prevent low blood sugar, eat meals on a regular schedule, and do not skip meals. Check with your doctor or pharmacist to find out what you should do if you miss a meal.

    Symptoms of low blood sugar include sudden sweating, shaking, fast heartbeat, hunger, blurred vision, dizziness, or tingling hands/feet. It is a good habit to carry glucose tablets or gel to treat low blood sugar. If you don't have these reliable forms of glucose, rapidly raise your blood sugar by eating a quick source of sugar such as table sugar, honey, or candy, or drink fruit juice or non-diet soda. Tell your doctor right away about the reaction and the use of this product.

    Symptoms of high blood sugar (hyperglycemia) include thirst, increased urination, confusion, drowsiness, flushing, rapid breathing, or fruity breath odor. If these symptoms occur, tell your doctor right away. Your dosage may need to be increased.

    A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any of the following symptoms of a serious allergic reaction: rash, itching/swelling (especially of the face/tongue/throat), dizziness, trouble breathing.

    This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

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    Product Description

    Common use

    Actos is used to control high blood sugar in type 2 diabetes (non-insulin-dependent diabetes mellitus). This form of the illness is usually caused by inability of the body to respond correctly to insulin: either the body does not produce enough insulin or the cells ignore the insulin. Insulin is the natural hormone that helps to transfer sugar out of the blood and into the cells, where it is metabolized to energy. Actos works by improving the response of the body to insulin, rather than increasing its insulin output. Actos also reduces the production of unneeded sugar in the liver.
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    Dosage and directions

    Take this medication by mouth, with or without food, usually one time a day. Follow all directions of your health care advisor as dosage is based on your medical condition, possible reaction to therapy, and can be corrected if you are treated by other anti-diabetic medications. Take this drug each time the same day as this way you will get the most benefit from it. Regularly monitor blood glucose levels. It may take up to 2 to 3 months before the full benefit is realized. Take all other medications for diabetes according to recommendations of your doctor.

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    Before taking Actos, tell your doctor or pharmacist if you are allergic to it; if you are allergic to other "glitazones" (such as rosiglitazone, troglitazone); or if you have any other types of allergy. Do not use Actos if you have certain medical conditions. Before starting treatment with Actos, notify you doctor or pharmacist if you have: type 1 diabetes (insulin-dependent diabetes), heart failure (acute congestive heart failure) either newly diagnosed or worsening, dangerously high blood glucose (diabetic ketoacidosis), liver dysfunctions. Before using this medication, tell your doctor or pharmacist your medical history, especially of: heart disease (chronic congestive heart failure), liver problems, fluid in your lungs, swelling (edema), anemia. Extremely low or high blood sugar levels may cause blurred vision, dizziness, or drowsiness; be cautious engaging in activities requiring alertness for example driving or operating machinery. Limit alcohol as much as possible when you are treated with this medication because it can increase the risk of developing hypoglycemia. If you have fever, infection, injury or surgery, it may complicate controlling of your blood sugar. Consult your doctor, as you may need correction of dose or a change in your medication may be required. Women with certain fertility problems may have changes in the menstrual cycle (ovulation) taking this medication. Consult your doctor or pharmacist about prescription of reliable contraception while you are taking Actos. This medication should be used in pregnant women only in life threating conditions. Discuss its risks and benefits with your physician. If you are pregnant your doctor may substitute insulin for Actos. Follow all instructions carefully. There are no reports whether this drug excretes with breast milk. Breastfeeding is not advised while using this drug. Before starting breastfeeding consult your physician.

    Possible side effects

    Actos side effects include rapid heartbeat, sweating, confusion, blurred vision, headache, numbness or tingling of the mouth, weakness,shakiness, dizziness, tiredness, paleness and sudden hunger.

    Missed dose

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    Seek emergency medical attention if you think you have taken too much of this medicine. You may have signs of low blood sugar, such as hunger, weakness, dizziness, headache, irritability, drowsiness, fainting, sweating, confusion, tremors, fast heartbeat, seizure (convulsions), or coma.

    Drug interactions

    Inform your health care advisor if you are taking any other anti-diabetic medications (insulin, metformin, or sulfonylureas such as glyburide), herbal/natural products (fenugreek, ginseng, gymnema). This medication is able to decrease the effectiveness of certain contraceptives which may result in pregnancy. Take care about additional form of reliable birth control while using Actos. Do not begin or discontinue an intake of any medicine without doctor or pharmacist approval.

    Storage

    Store at room temperature in a tight container, away from moisture and humidity.

    Disclaimer

    We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information on the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.
    Uses
    Pioglitazone is a diabetes drug (thiazolidinedione-type, also called "glitazones") used along with a proper diet and exercise program to control high blood sugar in patients with type 2 diabetes. It works by helping to restore your body's proper response to insulin, thereby lowering your blood sugar.

    Controlling high blood sugar helps prevent kidney damage, blindness, nerve problems, loss of limbs, and sexual function problems. Proper control of diabetes may also lessen your risk of a heart attack or stroke.

    Pioglitazone is used either alone or in combination with other diabetes medications (such as metformin or a sulfonylurea such as glyburide).

    Talk to your doctor about the risks and benefits of pioglitazone.

    How to use Actos
    Read the Medication Guide provided by your pharmacist before you start using pioglitazone and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

    Take this medication by mouth with or without food as directed by your doctor, usually once daily. Dosage is based on your medical condition, response to treatment, and if you are taking other diabetes drugs. Your doctor will adjust your dose based on your blood sugar to find the best dose for you. Follow your doctor's directions carefully.

    Take this medication regularly in order to get the most benefit from it. Remember to use it at the same time each day.

    If you are already taking another diabetes drug (such as metformin or a sulfonylurea), follow your doctor's directions carefully for stopping/continuing the old drug and starting this medication. Carefully follow the medication treatment plan, meal plan, and exercise program your doctor has recommended.

    Check your blood sugar regularly as directed by your doctor. Keep track of the results, and share them with your doctor. Tell your doctor if your blood sugar measurements are too high or too low. Your dosage/treatment may need to be changed. It may take up to 2 to 3 months before the full benefit of this drug takes effect.
    Side Effects
    See also Warning section.

    Sore throat, muscle pain, weight gain, or tooth problems may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.

    Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

    Tell your doctor right away if you have any serious side effects, including: new/worsening vision problems (such as blurred vision), bone fracture, reddish-colored urine, urgent need to urinate, pain while urinating.

    Pioglitazone may rarely cause liver disease. Tell your doctor right away if you develop symptoms of liver disease, including: dark urine, yellowing of eyes/skin, persistent nausea/vomiting, stomach/abdominal pain.

    Pioglitazone does not usually cause low blood sugar (hypoglycemia). Low blood sugar may occur if this drug is prescribed with other diabetes medications (such as insulin or a sulfonylurea). Low blood sugar is more likely if you drink large amounts of alcohol, do unusually heavy exercise, or do not consume enough calories from food. To help prevent low blood sugar, eat meals on a regular schedule, and do not skip meals. Check with your doctor or pharmacist to find out what you should do if you miss a meal.

    Symptoms of low blood sugar include sudden sweating, shaking, fast heartbeat, hunger, blurred vision, dizziness, or tingling hands/feet. It is a good habit to carry glucose tablets or gel to treat low blood sugar. If you don't have these reliable forms of glucose, rapidly raise your blood sugar by eating a quick source of sugar such as table sugar, honey, or candy, or drink fruit juice or non-diet soda. Tell your doctor right away about the reaction and the use of this product.

    Symptoms of high blood sugar (hyperglycemia) include thirst, increased urination, confusion, drowsiness, flushing, rapid breathing, or fruity breath odor. If these symptoms occur, tell your doctor right away. Your dosage may need to be increased.

    A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any of the following symptoms of a serious allergic reaction: rash, itching/swelling (especially of the face/tongue/throat), dizziness, trouble breathing.

    This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

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    What is ADALAT?
    INDICATIONS

    Adalat is used to treat hypertension (high blood pressure) and angina (chest pain). Adalat is in a class of drugs called calcium channel blockers. Adalat relaxes (widens) your blood vessels (veins and arteries), which makes it easier for the heart to pump and reduces its workload.

    INSTRUCTIONS

    Take Adalat exactly as prescribed by your doctor.

    Do not take in larger or smaller amounts or for longer than recommended.
    Your doctor may occasionally change your dose to make sure you get the best results.
    Take Adalat on an empty stomach. Do not crush, chew, or break a tablet. Swallow it whole. Breaking the pill may cause too much of the drug to be released at one time.
    Do not stop taking Adalat even if you feel fine. Stopping suddenly may make your condition worse. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life.
    Your blood pressure will need to be checked often and you may need other blood tests at your doctor's office. Visit your doctor regularly.
    If you miss a dose of Adalat, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
    Ask your health care provider any questions you may have about how to use Adalat.

    STORAGE

    Store Adalat at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Adalat out of the reach of children and away from pets.

    MORE INFO:

    Active Ingredient: Nifedipine.



    SAFETY INFORMATION

    Do NOT use Adalat if:

    you are allergic to any ingredient in Adalat.
    Some medical conditions may interact with Adalat. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

    if you are pregnant, planning to become pregnant, or are breast-feeding
    if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
    if you have allergies to medicines, foods, or other substances
    if you have kidney or liver disease (especially cirrhosis), coronary artery disease, congestive heart failure, or digestive problems
    if you have recently had or will be having surgery, or if you have recently stopped taking a beta-blocker (eg, propranolol).
    Some medicines may interact with Adalat. Tell your health care provider if you are taking any other medicines, especially any of the following:

    acarbose (Precose);
    cimetidine (Tagamet);
    fentanyl (Actiq, Duragesic, Fentora) or other narcotic pain medications;
    digoxin (Lanoxin);
    nefazodone;
    St. John's wort;
    rifabutin (Mycobutin), rifampin (Rifadin, Rifater, Rifamate) or rifapentine (Priftin);
    a blood thinner such as warfarin (Coumadin);
    an antibiotic such as clarithromycin (Biaxin), dalfopristin/quinupristin (Synercid), or erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin);
    antifungal medication such as fluconazole (Diflucan), itraconazole (Sporanox), or ketoconazole (Nizoral);
    a beta-blocker such as atenolol (Tenormin, Tenoretic), carvedilol (Coreg), labetalol (Normodyne, Trandate), metoprolol (Lopressor, Toprol), nadolol (Corgard), propranolol (Inderal, InnoPran), sotalol (Betapace), timolol (Blocadren), and others;
    a heart rhythm medication such as quinidine (Quin-G) or flecaininde (Tambocor);
    HIV/AIDS medicine such as atazanavir (Reyataz), delavirdine (Rescriptor), fosamprenavir (Lexiva), indinavir (Crixivan), nelfinavir (Viracept), or ritonavir (Norvir, Kaletra, or saquinavir (Invirase);
    medicines used to prevent organ transplant rejection, such as sirolimus (Rapamune) or tacrolimus (Prograf);
    other heart or blood pressure medications such as benazepril (Lotensin), diltiazem (Cartia, Cardizem), doxazosin (Cardura), or verapamil (Calan, Covera, Isoptin, Verelan); or
    seizure medication such as carbamazepine (Carbatrol, Tegretol), phenobarbital (Solfoton), or phenytoin (Dilantin).
    This list is not complete and other drugs may interact with Adalat. Tell your doctor about all medications you use.

    Important safety information:

    Adalat may cause dizziness or lightheadedness. These effects may be worse if you take it with alcohol or certain medicines. Use Adalat with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
    Proper dental care is important while you are taking Adalat. Brush and floss your teeth and visit the dentist regularly.
    Use Adalat with caution in the elderly.
    Adalat should not be used in children; safety and effectiveness in children have not been confirmed.
    Pregnancy and breast-feeding: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Adalat while you are pregnant. It is not known if Adalat is found in breast milk. If you are or will be breast-feeding while you use Adalat, check with your doctor. Discuss any possible risks to your baby.
    SIDE EFFECTS

    Get emergency medical help if you have any of these signs of an allergic reaction to Adalat: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

    Call your doctor at once if you have a serious side effect while using Adalat such as:

    worsening angina;
    feeling like you might pass out;
    feeling short of breath, swelling in your hands or feet;
    fast or pounding heartbeats;
    numbness or tingly feeling;
    jaundice (yellowing of the skin or eyes); or
    chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling.
    Less serious side effects may include:

    headache, dizziness;
    drowsiness, tired feeling;
    nausea, constipation, diarrhea, stomach pain;
    sleep problems (insomnia);
    mild rash or itching;
    joint pain, leg cramps;
    warmth, redness, or tingly feeling under your skin; or
    urinating more than usual.
    This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.
    Uses
    This medication is used to prevent certain types of chest pain (angina). It may allow you to exercise more and decrease the frequency of angina attacks. Nifedipine belongs to a class of medications known as calcium channel blockers. It works by relaxing blood vessels so blood can flow more easily. This medication must be taken regularly to be effective. It should not be used to treat attacks of chest pain when they occur. Use other medications (such as sublingual nitroglycerin) to relieve attacks of chest pain as directed by your doctor. Consult your doctor or pharmacist for details.

    Older adults should discuss the risks and benefits of this medication with their doctor or pharmacist, as well as other possibly safer forms of nifedipine (such as the long-acting tablets).

    How to use Adalat Capsule
    Take this medication by mouth, usually 3 times daily with or without food or as directed by your doctor. Swallow this medication whole. Do not crush, chew, or break the capsule.

    The dosage is based on your medical condition and response to treatment. Your doctor may gradually increase your dose. Follow your doctor's instructions carefully.

    Avoid eating grapefruit or drinking grapefruit juice while taking this medication unless your doctor instructs you otherwise. Grapefruit can increase the amount of certain medications in your bloodstream. Consult your doctor or pharmacist for more details.

    Use this medication regularly to get the most benefit from it. To help you remember, take it at the same times each day.

    Tell your doctor if your condition worsens (for example, your chest pain worsens or is more frequent).
    Side Effects
    Dizziness, flushing, weakness, swelling ankles/feet, constipation, and headache may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

    To reduce dizziness and lightheadedness, get up slowly when rising from a sitting or lying position.

    Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

    Tell your doctor right away if any of these unlikely but serious side effects occur: fast/irregular/pounding heartbeat, fainting.

    Tell your doctor right away if any of these rare but very serious side effects occur: vision changes.

    Although this medication is effective in preventing chest pain (angina), some people who already have severe heart disease may rarely develop worsening chest pain or a heart attack after starting this medication or increasing the dose. Get medical help right away if you experience: worsening chest pain, symptoms of a heart attack (such as chest/jaw/left arm pain, shortness of breath, unusual sweating).

    A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

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    What is this medicine?

    FLUTICASONE; SALMETEROL inhalation is for treating asthma that is not controlled with other asthma medicines or when more than one treatment is necessary. Fluticasone is a corticosteroid which decreases inflammation in the lungs. Salmeterol helps open the airways in the lungs. This medicine is intended for regular use. It will not cure your condition, but when used regularly it can open up your air passages and make breathing easier. It will not relieve an acute asthma attack. Fluticasone; salmeterol can be used along with other inhaled or oral asthma medications.

    What should I tell my health care provider before I take this medicine?

    They need to know if you have any of these conditions:
    an asthmatic attack or bronchospasm
    chicken pox or measles (recent exposure or infection)
    diabetes
    heart disease including high blood pressure, irregular heart beat, blockage in heart vessels
    immune system problems
    infection, especially fungal infection or tuberculosis
    liver disease
    osteoporosis or other bone disease
    overactive thyroid
    pheochromocytoma
    seizures
    an unusual or allergic reaction to Fluticasone, Salmeterol, other corticosteroids, other medicines, foods, dyes, or preservatives
    pregnant or trying to get pregnant
    breast-feeding

    How should this medicine be used?

    DO NOT use this medicine for an asthma attack. If you have severe onset or worsening of cough, wheezing, chest tightness, and/or shortness of breath seek immediate medical attention. Always keep a short-acting asthma medication such as albuterol on hand for asthma attacks.

    This medicine is for inhalation through the mouth. Shake the inhaler well for 5 seconds before each spray. Prime the inhaler before the first use with 4 test sprays pointing away from your face. If you drop the inhaler or of it has not been used for 4 weeks, prime it with 2 test sprays pointing away from your face. Avoid contact with eyes. After using the inhaler, rinse your mouth with water to minimize build-up of medicine; do not swallow the water. Clean your inhaler at least once a week. Never place the inhaler in water to determine how much medicine is in it. Do not use more than the recommended dose.

    Contact your pediatrician or health care professional regarding the use of this medicine in children. Special care may be needed.

    NOTE: This medicine is only for you. Don't share it with others.

    What if I miss a dose?

    If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, take only that dose and continue with your regular schedule, spacing doses evenly. Do not use double or extra doses.


    What may interact with this medicine?

    arsenic trioxide
    astemizole
    bepridil
    beta-blockers, often used for high blood pressure or heart problems
    caffeine
    certain antibiotics (such as clarithromycin, erythromycin, gatifloxacin, gemifloxacin, grepafloxacin, levofloxacin, linezolid, moxifloxacin, sparfloxacin)
    chloroquine
    cisapride
    droperidol
    halofantrine
    levomethadyl
    medicines for colds and breathing difficulties
    medicines for heart disease or high blood pressure
    medicines known as MAO inhibitors, such as phenelzine (Nardil®), tranylcypromine (Parnate®), isocarboxazid (Marplan®), and selegiline (Carbex®, Eldepryl®)
    medicines to control heart rhythm (examples: amiodarone, disopyramide, dofetilide, flecainide, procainamide, quinidine, sotalol)
    medicines for treating depression or mental illness (amoxapine, haloperidol, maprotiline, pimozide, phenothiazines, risperidone, sertindole, tricyclic antidepressants, ziprasidone)
    methadone
    pentamidine
    probucol
    some medicines for weight loss (including some herbal products, ephedra, ephedrine, dextroamphetamine)
    steroid hormones such as dexamethasone, cortisone, hydrocortisone
    terfenadine
    theophylline
    thyroid hormones
    water pills or diuretics

    Tell your prescriber or health care professional about all other medicines you are taking, including non-prescription medicines, nutritional supplements, or herbal products. Also tell your prescriber or health care professional if you are a frequent user of drinks with caffeine or alcohol, if you smoke, or if you use illegal drugs. These may affect the way your medicine works. Check with your health care professional before stopping or starting any of your medicines.

    What should I watch for while taking this medicine?

    Visit your prescriber or health care professional for regular checks on your progress. Carry an identification card with your name, the type and dose of medicine you are taking, and your prescriber's name and address. It can take up to 2 weeks before you see the full effect of this medicine.

    Check with your prescriber or health care professional if your symptoms do not improve. Seek emergency medical attention if your breathing problems get worse quickly while taking this medicine, or if your rescue inhaler (like albuterol) does not help your breathing. If you find that you are using your rescue inhaler more than normal or it is not as effective in treating your symptoms, you should contact your health care professional as soon as possible. You may need a change of therapy or may be having worsening of your lung condition. Do not stop using this medicine except on your prescriber's advice.

    Using your inhalers regularly as prescribed will help control your symptoms; try not to run out of your medications. It is recommended that you keep an extra refill of your inhalers on hand in case you need them.

    Tell your prescriber or health care professional if you are exposed to anyone with measles or chickenpox, or if you develop sores or blisters that do not heal properly.

    People who are taking certain dosages of this medicine may need to avoid getting certain vaccines or may need to have changes in their vaccination schedules to ensure adequate protection from certain diseases. Make sure to tell your prescriber or health care professional that you are taking fluticasone; salmeterol before receiving any vaccine.

    If you are going to have surgery tell your prescriber or health care professional that you are using this medicine.

    What side effects may I notice from this medicine?

    Side effects that you should report to your prescriber or health care professional as soon as possible:
    chest pain
    dizziness or lightheadedness
    fever or chills
    skin rash and itching (hives)
    sore mouth with white patches in the mouth or throat
    troubled breathing or wheezing
    unusual swelling
    unusual tiredness or weakness
    vision problems
    vomiting

    Side effects that usually do not require medical attention (report to your prescriber or health care professional if they continue or are bothersome):
    coughing, hoarseness, throat irritation
    diarrhea
    headache
    nausea
    nervousness
    sore throat
    stomach upset
    stuffy nose

    Where can I keep my medicine?

    Keep out of the reach of children in a container that small children cannot open.

    Store at room temperature between 15—30 degrees C (59—86 degrees F) with mouthpiece facing down. Keep away from heat or open flames.
    Uses
    This product is used to control and prevent symptoms (wheezing and shortness of breath) caused by asthma or ongoing lung disease (chronic obstructive pulmonary disease-COPD, which includes chronic bronchitis and emphysema). It contains 2 medications: fluticasone and salmeterol. Fluticasone belongs to a class of drugs known as corticosteroids. It works by reducing the irritation and swelling of the airways. Salmeterol belongs to the class of drugs known as long-acting beta agonists. It works by opening airways in the lungs to make breathing easier. Controlling symptoms of breathing problems can decrease time lost from work or school.

    When used alone, long-acting beta agonists (such as salmeterol) may rarely increase the risk of serious (sometimes fatal) asthma-related breathing problems. However, combination inhaled corticosteroid and long-acting beta agonists, such as this product, do not increase the risk of serious asthma-related breathing problems. For asthma treatment, this product should be used when breathing problems are not well controlled with one asthma-control medication (such as inhaled corticosteroid) or if your symptoms need combination treatment.

    Before using this medication, it is important to learn how to use it properly. This medication must be used regularly to be effective. It does not work right away and should not be used to relieve sudden asthma attacks. If an asthma attack occurs, use your quick-relief inhaler (such as albuterol, also called salbutamol in some countries) as prescribed.

    How to use Advair Diskus Blister, With Inhalation Device
    Read the Patient Information Leaflet and Instructions for Use provided by your pharmacist before you start using this medication and each time you get a refill. Follow the illustrated directions for the proper use of this medication. If you have any questions, ask your doctor or pharmacist.

    Use this device in a level, flat position. Inhale this medication by mouth as directed by your doctor, usually twice daily (in the morning and evening, 12 hours apart). You may or may not taste/feel the drug when you inhale. Either is normal. Do not exhale into the device.

    Do not take the inhaler apart or wash the mouthpiece or any part of the device. Close the device after each use.

    If you are using other inhalers at the same time, wait at least 1 minute between the use of each medication, and use this drug last.

    Gargle and rinse your mouth with water after each use of this medication to help prevent irritation and yeast infections (thrush) in the mouth and throat. Do not swallow the rinse water.

    The dosage is based on your medical condition, age, and response to treatment.

    Use this medication regularly in order to get the most benefit from it. This medication works best if used at evenly spaced times. To help you remember, use it at the same times each day. Do not increase your dose, use this medication more often, or stop using it without talking with your doctor. Also, do not use other long-acting beta agonists while using this medication.

    If you have been using a quick-relief inhaler (such as albuterol, also called salbutamol in some countries) on a regular daily schedule (such as 4 times daily), you must stop this schedule and only use the quick-relief inhaler as needed for sudden shortness of breath/asthma attacks. Consult your doctor for details.

    If you are regularly using a different corticosteroid taken by mouth (such as prednisone), you should not stop using it unless directed by your doctor. You may have withdrawal symptoms if the drug is suddenly stopped. Some conditions (such as asthma, allergies) may become worse when the drug is suddenly stopped. To prevent withdrawal symptoms (such as weakness, weight loss, nausea, muscle pain, headache, tiredness, dizziness), your doctor may direct you to slowly lower the dose of your old medication after you begin using this product. Consult your doctor or pharmacist for more details, and report any withdrawal reactions right away. See also Precautions section.

    It may take 1 week or longer before you get the full benefit of this drug. Tell your doctor if your condition does not improve or if it worsens.

    Learn which of your inhalers you should use every day (controller drugs) and which you should use if your breathing suddenly worsens (quick-relief drugs). Ask your doctor ahead of time what you should do if you have new or worsening cough or shortness of breath, wheezing, increased sputum, worsening peak flow meter readings, waking up at night with trouble breathing, if you use your quick-relief inhaler more often (more than 2 days a week), or if your quick-relief inhaler does not seem to be working well. Learn when you can treat sudden breathing problems by yourself and when you must get medical help right away.
    Side Effects
    Hoarseness, throat irritation, headache, or stomach upset may occur. If any of these effects persist or worsen, tell your doctor promptly.

    Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

    This medication may raise your blood pressure. Check your blood pressure regularly and tell your doctor if the results are high.

    Infrequently, this medication may cause severe sudden worsening of breathing problems/asthma immediately after use. If you have sudden worsening of breathing, use your quick-relief inhaler and get medical help right away.

    Tell your doctor right away if any of these unlikely but serious side effects occur: white patches on tongue/in mouth, signs of infection (such as fever, persistent sore throat), mental/mood changes (such as nervousness), trouble sleeping, vision problems (such as blurred vision), increased thirst/urination, muscle cramps, shaking (tremors).

    Get medical help right away if any of these rare but seriouschest pain, fast/irregular heartbeat, severe dizziness, fainting, seizures.

    A very serious allergic reaction to this product is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

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    Loratadine is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose. Alavert is used for relieving symptoms of seasonal allergies.

    INSTRUCTIONS

    Use exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

    Do not crush, chew, or break the regular loratadine tablet. Swallow the pill whole.
    Measure liquid medicine with a special dose-measuring spoon or medicine cup, not with a regular table spoon.

    Alavert is usually taken once per day. Follow your doctor's instructions.

    To take Alavert orally disintegrating tablet:

    Keep the tablet in its blister pack until you are ready to take the medicine. Open the package and peel back the foil from the tablet blister. Do not push a tablet through the foil or you may damage the tablet.
    Do not swallow the tablet whole. Allow it to dissolve in your mouth without chewing.
    Do not swallow the tablet whole. Allow it to dissolve in your mouth without chewing.
    Using dry hands, remove the tablet and place it on your tongue. It will begin to dissolve right away.
    Take Alavert by mouth with food.
    STORAGE

    Store at room temperature between 20 and 25 degrees C and away from moisture, light and heat. Do not store in the bathroom. Keep in a tight, light-resistant container. Keep Alavert out of the reach of children and away from pets.



    SAFETY INFORMATION

    You should not take Alavert if:

    You are allergic to loratadine or to desloratadine (Clarinex).
    Ask a doctor or pharmacist if it is safe for you to take this medicine if you have:

    kidney disease;
    Ask a doctor or pharmacist if it is safe for you to take this medicine if you have:


    kidney disease;
    liver disease.
    You should not take this medication if you are allergic to loratadine or to desloratadine (Clarinex).

    FDA pregnancy category B: This medication is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Loratadine can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

    Loratadine disintegrating tablets (Claritin Reditab, Alavert) may contain phenylalanine. Talk to your doctor before using this form of loratadine if you have phenylketonuria (PKU).
    Do not give this medication to a child younger than 6 years old without the advice of a doctor.

    SIDE EFFECTS

    All medicines may cause side effects, but many people have no, or minor, side effects.

    Check with your doctor if any of these most common side effects persist or become bothersome:

    fast or uneven heart rate;
    feeling like you might pass out;
    jaundice (yellowing of your skin or eyes);
    seizures (convulsions).
    Call your doctor at once if you noticed these serious side effects. Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

    Less serious side effects may include:

    headache;
    skin rash;
    nervousness;
    nosebleed;
    feeling tired or drowsy;
    eye redness, blurred vision;
    stomach pain, diarrhea;
    dry mouth, sore throat hoarseness.
    Uses
    Loratadine is an antihistamine which provides relief of seasonal allergy symptoms such as watery and itching eyes, runny nose, and sneezing. Pseudoephedrine is a decongestant which helps relieve a stuffy nose, promotes sinus draining, and improves breathing.

    This medication is not recommended for use in children under 12 years of age due to the high amount of pseudoephedrine.

    How to use Alavert
    Take this medication by mouth as directed by your doctor, usually twice daily (every 12 hours) with a full glass of water.

    Do not crush or chew this medication. Doing so can release all of the drug at once, increasing the risk of side effects. Also, do not split the tablets unless they have a score line and your doctor or pharmacist tells you to do so. Swallow the whole or split tablet without crushing or chewing.

    Do not increase your dose or take this more often than directed.

    Do not take this medication for several days before allergy testing since test results can be affected. Consult your doctor or pharmacist for more information.
    Side Effects
    Dry mouth, mild stomach upset, trouble sleeping, dizziness, headache, nervousness, loss of appetite, or thirst may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.

    If your doctor has directed you to use this medication, remember that he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

    Tell your doctor right away if any of these serious side effects occur: fast/irregular heartbeat, uncontrolled shaking or tremor.

    Tell your doctor right away if any of these unlikely but serious side effects occur: seizures, mental/mood changes (such as confusion), difficulty urinating.

    This medication does not usually cause drowsiness when used at recommended doses and under normal circumstances. However, this drug may make you dizzy; therefore use caution engaging in activities that require alertness such as driving or using machinery.

    A serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction include: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

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    ANTABUSE: Side Effects, Drug Information - Medical News Today!
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    What is ANTABUSE?
    INDICATIONS

    Antabuse is used for treating alcoholism. Antabuse is an alcohol-abuse deterrent. It works by blocking the breakdown of alcohol, causing unpleasant side effects (eg, vomiting, upset stomach) when even a small amount of alcohol is consumed.

    INSTRUCTIONS

    Use Antabuse as directed by your doctor.

    Antabuse may be taken with or without food.
    Antabuse may be swallowed whole, chewed, or crushed and mixed with food.
    Do not take the first dose of Antabuse for at least 12 hours after drinking alcohol.
    If you miss a dose of Antabuse, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
    Ask your health care provider any questions you may have about how to use Antabuse.

    STORAGE

    Store Antabuse at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Antabuse out of the reach of children and away from pets.

    MORE INFO:

    Active Ingredient: Disulfiram.

    SAFETY INFORMATION

    Do NOT use Antabuse if:

    you are allergic to any ingredient in Antabuse or other similar medicines
    you are under the influence of alcohol
    you have severe heart disease, a blockage of your heart arteries, or a mental disorder (eg, psychosis)
    you are taking metronidazole or an alcohol-containing medicine (eg, certain HIV protease inhibitors [eg, amprenavir], cough syrups, other liquid medicines).
    Contact your doctor or health care provider right away if any of these apply to you.

    Some medical conditions may interact with Antabuse. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

    if you are pregnant, planning to become pregnant, or are breast-feeding
    if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
    if you have allergies to medicines, foods, or other substances (eg, latex rubber)
    if you have brain damage, diabetes, heart or lung disease, mental or mood problems (eg, depression), an underactive thyroid, seizures, or liver or kidney problems.
    Some medicines may interact with Antabuse. Tell your health care provider if you are taking any other medicines, especially any of the following:

    Alcohol-containing medicines (eg, certain HIV protease inhibitors [eg, amprenavir], cough syrups, other liquid medicines) or metronidazole because the risk of severe side effects may be increased
    Anticoagulants (eg, warfarin), benzodiazepines (eg, diazepam), isoniazid, or phenytoin because side effects may be increased by Antabuse.
    This may not be a complete list of all interactions that may occur. Ask your health care provider if Antabuse may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

    Important safety information:

    Antabuse may cause drowsiness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Antabuse. Using Antabuse alone, with certain other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks.
    Avoid all alcohol including alcohol found in sauces, vinegar, mouthwash, liquid medicines, lotions, after shave, or backrub products. A reaction to alcohol may cause flushing, nausea, thirst, abdominal pain, chest pain, dizziness, vomiting, fast breathing, fast heartbeat, fainting, difficulty breathing, or confusion. Use caution when using topical products containing alcohol, such as cologne or perfume. Before using alcohol-containing products on the skin, test the product by applying some to a small area of the skin. If no redness, itching, headache, or nausea occurs after 1 or 2 hours, you should be able to use the product. You may have a reaction if you drink alcohol or use a product that contains alcohol for 2 weeks after your last dose of Antabuse.
    Notify your doctor immediately if you experience yellowing of the skin or eyes, dark urine, weakness, tiredness, loss of appetite, or nausea and vomiting. These may be signs of a liver problem.
    Before you have any medical or dental treatments, emergency care, or surgery, tell the doctor or dentist that you are using Antabuse.
    Lab tests, including liver function tests and complete blood cell counts, may be performed to monitor your progress or to check for side effects. Be sure to keep all doctor and lab appointments.
    Pregnancy and breast-feeding: If you become pregnant, discuss with your doctor the benefits and risks of using Antabuse during pregnancy. It is unknown if Antabuse is excreted in breast milk. Do not breastfeed while taking Antabuse.
    SIDE EFFECTS

    All medicines may cause side effects, but many people have no, or minor, side effects.

    Check with your doctor if any of these most common side effects persist or become bothersome:

    Drowsiness; headache; metallic or garlic taste in mouth.

    Seek medical attention right away if any of these severe side effects occur:

    Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blurred vision; changes in color vision; dark urine; loss of appetite; mental or mood problems; nausea; numbness or tingling of the arms or legs; seizures; tiredness; vomiting; weakness; yellowing of the eyes or skin.

    This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.
    Uses
    This medication is used along with counseling and support to treat alcoholism. Disulfiram works by blocking the processing of alcohol in the body. This causes you to have a bad reaction when you drink alcohol.

    How to use Antabuse
    See also Precautions section.

    Take this medication by mouth with or without food, usually once daily in the morning or as directed by your doctor. If this medication causes drowsiness, take it at bedtime.

    Dosage is based on your medical condition and response to therapy. The maximum recommended daily dose is 500 milligrams.

    Use this medication regularly to get the most benefit from it. To help you remember, take it at the same time each day.
    Side Effects
    Drowsiness, tiredness, headache, acne, and metallic/garlic-like taste in the mouth may occur as your body gets used to the medication. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

    Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

    Tell your doctor right away if any of these unlikely but serious side effects occur: decreased sexual ability, vision changes, numbness/tingling of arms/legs, muscle weakness, mental/mood changes (e.g., agitation, extreme excitement/confusion), seizures, confusion.

    This drug may rarely cause serious (rarely fatal) liver disease. If you notice any of the following unlikely but very serious side effects, tell your doctor right away: persistent nausea/vomiting, severe stomach/abdominal pain, dark urine, yellowing eyes/skin.

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    Product Description

    Common use
    Allopurinol is an arthrifuge which inhibits xanthine oxidase and prevents formation of uric acid, from xanthine and hypoxanthine. Reduces the concentration of uric acid and its salts in body fluids, promotes the dissolution of existing urate deposits and prevents their formation in tissues and kidneys. The medication is used to treat diseases accompanied by hyperuricemia: gout (primary and secondary), nephrolithiasis (forming of kidney stones from urates); hyperuricemia (abnormally high level of uric acid in blood, both primary and secondary), which results in diseases involving enhanced dissolution of nucleoproteins and elevated levels of uric acid in the blood, including at various forms of leukemias, and also for treatment of some other conditions.

    Dosage and direction

    The dose of 100-800 mg a day may be prescribed depending on the condition. Initial dose of 100 mg can be increased gradually. Patients with acute gout and tophi (uric acid crystals in the tissues mostly around joints) should be treated with 300-400 mg of Allopuionol daily. Doses over 300 mg should be divided in two or more intakes. Take medication with food to avoid irritation of the stomach. Do not take large doses of vitamin C. Drink plenty of water to avoid formation of kidney stones. Limit consummation of alcoholic beverages and purine-rich foods such as sweetbreads, sardines, anchovies, kidneys, liver, and lentils.

    Precautions

    Allopurinol should be taken over a period of several months so your symptoms start to reduce. Regular intake is important even if no immediate effect is noticed. You may experience acute attacks of gout more often at the beginning of treatment with Allopurinol even after normal uric acid levels are reached. The attacks will become shorter and less acute as the therapy continues. At any sign of allergic reaction stop taking the medication and consult your doctor as development of serious skin disease, irreversible damage to the liver, or generalized inflammation of a blood or lymph vessel is possible in some individuals. Inform your doctor if you have diabetes or kidney dysfunction before taking Allopurinol as correction of your dose is needed.

    Contraindications

    Allopurinol cannot be used in patients with hypersensitivity to the medication, in individuals with a hepatic or renal disorders, primary hemochromatosis, asymptomatic hyperuricemia, acute gout, pregnancy, lactation. The medication cannot be prescribed to children under 14 years of age unless the patients are treated for leukemia, malignant tumors and enzymatic disorders. C care. Renal failure, heart failure, diabetes mellitus, hypertension.

    Possible side effect

    The most common adverse reactions are diarrhea, nausea, allergy (rash, itching), and drowsiness. Stop taking the medication at first signs of rash, painful or bloody urination, eye irritation, or facial swelling, because these can be signs of a severe allergic reaction requiring immediate treatment. In rare cases Allopurinol can cause damage to nerve, kidney, and bone marrow as well as be a reason to a serious and even fatal allergic liver toxicity. In patients with liver toxicity appetite loss and itching may witness about it. The risk increases in patients with kidney impairment.

    Drug interaction

    The dose of oral mercaptopurine (Purinethol) and azathioprine (Imuran) should be reduced as Allopurinol increases their blood levels. Risk of skin rash increases in patients taking Allopurinol with penicillins.

    Missed dose

    Take the missed dose as soon as you remember unless it is almost time of your next dose. If it is almost time of your next dose just skip it and return to your regular scheme. Do not exceed the recommended dose.

    Overdose

    In case of suspected overdose seek for immediate medical attention. No specific information is available about Allopurinol overdose.

    Storage

    Store at room temperature, below 25 C (77 F) and out of reach and children and pets.

    Disclaimer

    We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information on the site cannot be used for self-treatment and self-diagnosis.All specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.
    Uses
    Allopurinol is used to treat gout and certain types of kidney stones. It is also used to prevent increased uric acid levels in patients receiving cancer chemotherapy. These patients can have increased uric acid levels due to release of uric acid from the dying cancer cells. Allopurinol works by reducing the amount of uric acid made by the body. Increased uric acid levels can cause gout and kidney problems.

    How to use Allopurinol
    Take this medication by mouth, usually once daily or as directed by your doctor. Take this medication after a meal to reduce stomach upset. If your dose is more than 300 milligrams a day, you will need to take several smaller doses during the day to get this amount (ask your doctor for directions).

    It is best to drink a full glass of water with each dose and at least 8 more glasses (8 ounces each) of fluid a day. If your doctor has directed you to drink less fluid for other medical reasons, consult your doctor for further instructions. Your doctor may also instruct you on how to decrease acid in your urine (e.g., avoiding large amounts of ascorbic acid/vitamin C).

    Dosage is based on your medical condition and response to treatment. Use this medication regularly to get the most benefit from it. To help you remember, take it at the same time(s) each day.

    For the treatment of gout, it may take up to several weeks for this medicine to have an effect. You may have more gout attacks for several months after starting this medicine while the body removes extra uric acid. Allopurinol is not a pain reliever. To relieve pain from gout, continue to take your prescribed medicines for gout attacks (e.g., colchicine, ibuprofen, indomethacin) as directed by your doctor.
    Side Effects
    Stomach upset, nausea, diarrhea, or drowsiness may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

    Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

    Tell your doctor right away if any of these rare but very serious side effects occur: numbness/tingling of arms/legs, easy bleeding/bruising, signs of infection (e.g., fever, persistent sore throat), unusual tiredness, signs of kidney problems (such as change in the amount of urine, painful/bloody urination), yellowing eyes/skin, severe stomach/abdominal pain, persistent nausea/vomiting, dark urine, unusual weight loss, eye pain, vision changes.

    This medication can commonly cause a rash that is usually not serious. However, you may not be able to tell it apart from a rare rash that could be a sign of a severe reaction. Get medical help right away if you develop any rash.

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